منابع مشابه
Similarity Measure for Cell Membrane Fusion Proteins Identification
This work proposes a similarity measure between secondary structures of proteins capable of fusing cell membranes and its implementation in a classification system. For the evaluation of the metric we used secondary structures estimated from amino acid sequences of Class I and Class II viral fusogens (VFs), as well as VFs precursor proteins. We evaluated three different classifiers based on k-N...
متن کاملSequence similarity in structurally dissimilar proteins
It is a central tenet of protein evolution that the threedimensional structure of a protein family is better conserved than the sequences themselves. So structural similarities between related proteins should be detectable over longer evolutionary distances and be most useful for the functional prediction of proteins without closely related homologs. Comparative sequence and structural analysis...
متن کاملSearch for structural similarity in proteins
MOTIVATION The expanding protein sequence and structure databases await methods allowing rapid similarity search. Geometric parameters-dihedral angle between two sequential peptide bond planes (V) and radius of curvature (R) as they appear in pentapeptide fragments in polypeptide chains-are proposed for use in evaluating structural similarity in proteins (VeaR). The parabolic (empirical) functi...
متن کاملSignificant similarity and dissimilarity in homologous proteins.
Common practice emphasizes significant sequence similarities between different members of protein families. These similarities presumably reflect on evolutionary conservation of structurally and functionally essential residues. The nonconserved regions, on the other hand, may be either selectively neutral or differentiated. We propose several distributional sequence statistics (e.g., clustering...
متن کاملMembrane proteins in senescent erythrocytes.
The examination of erythrocyte senescence has been facilitated by recent advances in techniques for the isolation of aged red cells. One of these methods, which uses biotinylated rabbit erythrocytes, has been used to examine the state of membrane proteins in effete cells. These aged red cells were found to have normal ratios of alpha-spectrin and beta-spectrin as well as normal levels of ankyri...
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ژورنال
عنوان ژورنال: Nature
سال: 1989
ISSN: 0028-0836,1476-4687
DOI: 10.1038/342624a0